THANKFUL. The streaking Buffalo Bills will inch closer to clinching their fifth straight AFC East title Sunday.

The 9-2 Bills go for double figures in wins against the San Francisco 49ers in friendly Highmark Stadium.

The injury-hobbled 49ers will struggle mightily after their cross country holiday journey.

Expect another double-figure victory for league MVP candidate Josh Allen and his talented friends.

FREDDIE sees it this way:

BILLS 28, 49ers 17

HOME teams are capitalized. Teams picked to win the game are listed first, followed by the expected margin of victory. The official Las Vegas odds are in parentheses.

COLLEGES

Friday

COLORADO +13 over Oklahoma St. (+16.5)

OLE MISS +20 over Mississippi St. (+26)

GEORGIA +14 over Georgia Tech (+19.5)

Saturday

OHIO STATE +18 over Michigan (+21)

Tennessee +3 over VANDERBILT (+10.5)

Illinois +5 over NORTHWESTERN (+7.5)

CLEMSON +3 over South Carolina (+2.5)

Notre Dame +10 over USC (+7.5)

PENN STATE +31 over Maryland (+25)

OREGON +14 over Washington (+19)

WEEK: 8-2 (.800). Vs. line 5-5 (.500).

YEAR: 93-27 (.775). Vs. line 55-65 (.458).

PROS

Thursday

DETROIT +7 over Chicago (+10)

DALLAS +6 over NY Giants (+3.5)

GREEN BAY +6 over Miami (+3.5)

Friday

KANSAS CITY +7 over Las Vegas (+12.5)

Sunday

BUFFALO +11 over San Francisco (+7)

Houston +3 over JACKSONVILLE (+5)

ATLANTA +1 over LA Chargers (-2.5)

WASHINGTON +7 over Tennessee (+5.5)

MINNESOTA +3 over Arizona (+3.5)

NEW ENGLAND +3 over Indianapolis (-2.5)

CINCINNATI +6 over Pittsburgh (+3)

NEW ORLEANS +3 over LA Rams (-2.5)

NY JETS +7 over Seattle (+2.5)

Tampa Bay +5 over CAROLINA (+6)

BALTIMORE +7 over Philadelphia (+3)

Monday

DENVER +3 over Cleveland (+5)

WEEK: 8-5 (.615). Vs. line 6-7 (.462).

YEAR: 117-64 (.646). Vs. line 92-89 (.508).